Niacinamide Serum

Unlock the Power of Radiant Skin with AMORY - Niacinamide Serum

Introducing AMORY, your ticket to skin transformation! This remarkable serum, carefully crafted by Sokörpe Laboratories, brings together a powerful blend of ingredients to address a wide range of skin concerns. From acne to uneven skin tone, this superhero serum has you covered.

The AMORY Advantage:

• Niacinamide (Vitamin B3): This superstar ingredient helps improve the appearance of enlarged pores, uneven skin tone, fine lines, and dullness. It also supports the skin's natural barrier, keeping it strong and resilient.

• N-Acetyl Glucosamine: Working in harmony with niacinamide, N-Acetyl Glucosamine is known for its skin-brightening and hydration-boosting properties. Together, they tackle dark spots and promote a more even complexion.

• Zinc PCA: Say goodbye to excess oil and acne troubles! Zinc PCA regulates oil production, helps prevent breakouts, and soothes irritated skin.

• Allantoin: Known for its skin-soothing abilities, allantoin calms and hydrates the skin. It's a perfect addition to keep your skin feeling comfortable and nurtured.

What AMORY Can Do for You:

• Clearer Skin: AMORY is your go-to solution for acne-prone skin. It helps reduce the appearance of blemishes, prevents future breakouts, and promotes a clearer complexion.

• Even Skin Tone: Say farewell to uneven skin tone and dark spots. AMORY's potent combination of niacinamide and N-Acetyl Glucosamine brightens your skin and evens out pigmentation irregularities.

• Youthful Glow: Bid adieu to fine lines and dullness. AMORY supports collagen production and revitalizes your skin, leaving it looking more youthful and radiant.

• Hydration and Comfort: Allantoin and other hydrating ingredients keep your skin happy and comfortable, even if you have sensitive skin.

Experience the AMORY Difference:

AMORY is more than a serum; it's your partner in achieving the radiant, healthy skin you deserve. Say hello to clearer, more even, and youthful-looking skin with AMORY by Sokörpe. Unlock the power of radiant skin today!

 How to Apply Sokörpe's AMORY - Niacinamide Serum:

1.   Cleanse: Start with a clean face. Use your favorite gentle cleanser to remove dirt, oil, and makeup.

2.   Tone (Optional): If you use a toner as part of your skincare routine, apply it after cleansing and before AMORY.

3.   Dispense: Gently shake the bottle of AMORY to ensure all the beneficial ingredients are well-mixed. Open the bottle and hold the dropper vertically, allowing the serum to fill the dropper.

4.   Application: Place a single drop of AMORY serum on each of the following areas: under each eye, on your forehead, on each cheek, and on your neck.

5.   Avoid Touching: Make sure the dropper doesn't touch your skin to maintain the serum's hygiene.

6.   Spread: With clean fingertips, gently spread the serum across the designated areas.

7.   Massage: Use upward and outward motions when massaging the serum into your skin. This encourages better absorption and circulation.

8.   Allow Absorption: Give the serum a moment to absorb fully into your skin. You'll notice that it's lightweight and absorbs quickly.

9.   Follow with Moisturizer: After AMORY has fully absorbed, you can apply your favorite moisturizer. This seals in the benefits and keeps your skin hydrated.

10.                     Sun Protection (Morning Application): If you're applying AMORY in the morning, it's crucial to follow up with a mineral-based sunscreen. This helps protect your skin from UV damage.

Frequency: You can use AMORY twice a day, in the morning and evening, for optimal results.

Pairing: For a comprehensive skincare routine, apply AMORY after your Hyaluronic Acid serum and before your moisturizer. This allows the active ingredients to work effectively.

By following these simple steps, you can harness the full potential of Sokörpe's AMORY serum to address your skincare concerns effectively and maintain a radiant complexion.

Niacinamide is a cell-communicating ingredient that's been shown to increase the ceramide and fatty acid levels within skin to prevent dryness and stimulate microcirculation in the dermis. Niacinamide has the ability to fight acne, aging, water loss and discoloration. Niacinamide, also known as nicotinamide, is the precursor of important cofactors niacinamide adenosine dinucleotide (NAD) and its phosphate derivative, niacinamide adenosine dinucleotide phosphate (NADP). These cofactors and their reduced forms (NADH and NADPH) serve as reduction-oxidation (redox) coenzymes in more than 40 cellular biochemical reactions. Thus, niacinamide has the potential to exert multiple effects on skin and is a promising anti-aging cosmeceutical ingredient.

Niacinamide is also a component of important coenzymes involved in hydrogen transfer. Topical application of Sokörpe’s Niacinamide Serum has a stabilizing effect on epidermal barrier function, seen as a reduction in transepidermal water loss and an improvement in the moisture content of the horny layer. Niacinamide leads to an increase in protein synthesis (e.g. keratin), has a stimulating effect on ceramide synthesis, speeds up the differentiation of keratinocytes, and raises intracellular NADP levels. In ageing skin, topical application of niacinamide improves the surface structure, smoothes out wrinkles and inhibits photocarcinogenesis. It is possible to demonstrate anti-inflammatory effects in acne, rosacea and nitrogen mustard-induced irritation.

N-Acetyl Glucosamine (NAG) is considered to be a “skin identical ingredient”, meaning it is found in our skin in the spaces between the cells, and it is used to maintain skin’s barrier abilities and reduce dryness. N-Acetyl Glucosamineis an amino-monosaccharide (simple sugar) and a precursor of hyaluronic acid (meaning it helps skin make hyaluronic acid). Hyaluronic acid is a fundamental component of skin since it is responsible for helping skin to maintain normal hydration and elasticity.

Zinc PCA has long been used as a cosmetic ingredient because of its astringent and anti-microbial properties, and zinc itself exerts protective effects on UV damage in keratinocytes and fibroblasts in vitro and in vivo

Allantoin is an effective anti-irritant for the skin, calming and soothing sensitive areas. It has been used to effectively help promote wound healing, and because it helps with cell regeneration, it has been used on treatments for skin which has suffered abrasions or burns. It has also been shown to calm eczema and other skin ailments.

While the basic benefits of allantoin remove dead skin cells, it goes way beyond the capabilities of an alpha hydroxy acid exfoliator! It has the added benefit of promoting additional moisture in the area between cells, which helps keep your skin from experiencing transepidermal water loss, or moisture evaporating from the surface of the skin.
What's that mean for your skin? The skin conditioning properties help reduce acne flare-ups and aid in soothing rosacea and psoriasis while the stimulation of new cells triggers your body to produce more collagen. This smooths the appearance of fine lines and wrinkles, while the ceramides retain moisture to prevent skin dehydration and sagging.

Key Ingredients (53% Organic):
10% Niacinamide (Vitamin B3)
2% N-Acetyl Glucosamine (NAG)
1% Zinc PCA
Sodium Ascorbyl Phosphate (Vitamin C)
Panthenol (Provitamin B5)
MSM (Organic Sulfur)
Organic Hyaluronic Acid (Sodium Hyaluronate) / Triple Molecular Weights
Amino Acid Complex (7 skin benefiting amino acids)
Vitamin E
Beta-Glucan
Phytoceramides
Adenosine
Bisabolol
Carnosine

Other Key Ingredients:
Allantoin

Base:
Organic Aloe Vera Juice
Organic Bulgarian Rose Distillate
Organic Witch Hazel Extract

Botanical Extracts:
Organic Green Tea
Organic Roman Chamomile
Organic Tamarind Seed
Organic Comfrey Root
Organic Holy Basil
Organic Dandelion Root

Natural Oils:
Organic Rosehip Seed Oil
Organic Squalane (Vegetable Derived)

Scent:
Geranium Essential Oil
Clary Sage Essential Oil

Clinical Information:

Clinical studies under Feldmann et al highlighted the possibilities for the topical application of niacinamide because they were able to prove sufficient percutaneous penetration into human skin. In addition, several other studies have used increased levels of NAD in skin cells after the topical application of niacinamide as evidence of percutaneous penetration.

What are the potential mechanisms of action of niacinamide?

Studies have shown that niacinamide has the potential to act as an antioxidant, can improve epidermal barrier function, decrease skin hyperpigmentation, reduce fine lines and wrinkles, decrease redness/blotchiness, decrease skin yellowness (sallowness), and improve skin elasticity. The mechanisms by which niacinamide provides this array of skin benefits is not completely understood, but the role of niacinamide as a precursor to the NADP family of coenzymes may play a significant role in all of these improvements.

Antioxidant capacity. Niacinamide increases the antioxidant capacity of skin after topical application by increasing the reduced forms (NADPH), which have potent antioxidant properties. This is probably the most well-studied anti-aging effect of niacinamide.

Epidermal barrier function. Niacinamide may improve the skin barrier function in two ways: first, by its ability to up-regulate the synthesis of ceramides as well as other SC intercellular lipids, and second, by stimulating keratinocyte differentiation. Ceramides and other intercellular SC lipids are known to play a central role in the structural and functional integrity of the epidermal barrier function. The responsible mechanism for the increase of ceramide synthesis in niacinamide-treated, cultured keratinocytes was found to be based on the upregulation of serine palmitoyltransferase, the rate-limiting enzyme in sphingolipid synthesis. The increase in ceramide synthesis has been confirmed in an in-vivo trial after topical application of 2% niacinamide emulsion for four weeks applied twice daily. The elevation of ceramides after treatment with niacinamide is associated with an improved barrier function as evidenced by a reduced TEWL and an increase in the cutaneous resistance to potential harmful topical agents. The second mechanism likely responsible for improved barrier function is a stimulation of keratinocyte differentiation seen both in cell cultures in vitro and in-vivo studies conducted by Tanno et al. In cell cultures, more rapid keratinocyte differentiation following treatment with niacinamide was established. In particular, it was possible to determine an influence on keratin, K1. K1 is a basic keratin synthesized mainly in the lowest layers of the stratum spinosum. The functional limitations of aging skin include reduced “turnover of the epidermis” (i.e., a slower epidermal cell cycle) due to a deficiency of NADP in aging cells. Tanno et al also demonstrated an in-vivo improvement in epidermal barrier function with improved keratinocyte differentiation after the application of topical niacinamide. Once again, the improved barrier function was evident by a decrease in TEWL and increase in SC moisture content. Similar results were also obtained by Ertel et al. In conclusion, it seems that topical application of niacinamide increases NADP levels, which in turn stimulates keratinocyte differentiation. This results in a thicker SC, which is not only associated with an improved barrier, but is also associated with greater hydration retention capacity in the SC.

Erythema and blotchiness. The mechanism by which redness/blotchiness is improved may be related to the improved skin barrier function for reasons discussed above. Increased barrier function may mean less irritation and redness when the skin encounters environmental insults, such as detergents and soaps, and hence less reddening of the skin. However, this theory has not been substantiated.

Yellowing of skin. The yellowing of skin that comes with aging may be a result of glycation of proteins in the skin called the Maillard reaction. The Maillard reaction is a spontaneous oxidative reaction between protein and sugar that results in cross-linked proteins (Amadori products) that are yellowish-brown in color and are fluorescent. These proteins can accumulate in the skin matrix components, similar to collagen, in response to oxidative stress as we age. Published data show a fivefold increase in collagen oxidation products in human skin from age 20 to 80. Since NADH and NADPH are antioxidants and their levels can be increased with niacinamide, a possible effect of topical niacinamide is inhibition of oxidative processes, such as protein oxidation, glycation, and the Maillard reaction, and hence the inhibition of skin yellowing.

Fine lines and wrinkles. Multiple mechanisms may be involved in the ability of niacinamide to reduce the appearance of fine lines and wrinkles. The first to consider is that niacinamide may have the ability to increase dermal collagen and protein production. The development of wrinkles is a result of the decrease in epidermal cell layers and dermal components from a reduction in protein and collagen synthesis. Reduced protein synthesis is reflected in the levels of keratin, fillagrin, and involucrin in the skin. Keratin deficiency has an effect on the epidermal cell structure and its water-binding capacity. Fillagrin is an antecedent of natural moisturizing factor (NMF) and hence affects skin hydration. Involucrin is seen as significant for the cell envelope and structure of the SC. In summary, the effects of reduced collagen and protein synthesis are poor skin structure and reduced skin elasticity as well as a decrease in epidermal barrier function with a reduction in SC hydration. In studies on cell cultures, Oblong et al found that in aging cells it was possible to prove that niacinamide, as a precursor of NAD/NADP, stimulated collagen synthesis and the epidermal proteins keratin, fillagrin, and involucrin. In addition, another study was able to show niacinamide's ability to increase dermal matrix collagen production.

The second mechanism that may be relevant to decreasing the appearance of wrinkles is the ability of niacinamide to reduce excess dermal glycosaminoglycans (GAGs). This is a controversial theory because both the elevation and depletion of dermal GAGs are associated with photodamaged or wrinkled skin. What is known is that the presence of GAGs is required for normal structure and function of the dermal matrix and increasing the levels of GAGs can increase the moisture content of skin. Testing has indicated that niacinamide reduces excess production of GAGs in old human dermal fibroblasts, thus supporting the potential involvement of this mechanism in reducing the appearance of fine lines and wrinkles. Given the above analysis and scientific data, it seems more likely that an increase in dermal proteins (including collagen) may play a bigger role in reducing fine lines and wrinkles than decreasing the level of GAGs.

Hyperpigmentation. Topical niacinamide may be effective in decreasing epidermal hyperpigmentation and reducing pigmented spots as we age. Hakozaki et al showed that the reduction of cutaneous pigmentation, surprisingly, was not due to the direct influence of niacinamide on melanin synthesis by melanocytes. Instead, they showed that niacinamide reduced melanosome transfer from melanocytes to surrounding keratinocytes in a co-culture system, although the specific mechanism remains unknown. This was supported by a study using 5% niacinamide moisturizer, which provided 35 to 68 percent inhibition of melanosome transfer from melanocytes to keratinocytes.